1-substituted oxindole-3-carboxamides as antiinflammatory...

Details 1-substituted oxindole-3-carboxamides as antiinflammatory... 1-substituted oxindole-3-carboxamides as antiinflammatory...

C - Chemistry, Metallurgy

07

D

167/231, 167/240

C07D 209/42 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1286663

1-SUBSTITUTED OXINDOLE-3-CARBOXAMIDES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS Abstract A series of 1-substituted oxindole-3-carboxamide compounds are useful as antiinflammatory and analgesic agents in mammalian subjects. The compounds of the invention can be prepared by (1) reaction of the appropriate 1-substituted oxindole with an isocyanate or (2) aminolysis of the alkyl ester of the appropriate 1-substituted oxindole-3-carboxylate.

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