Process for the preparation of compounds containing...

Details Process for the preparation of compounds containing... Process for the preparation of compounds containing...

C - Chemistry, Metallurgy

07

K

530/5.04, 260/46

C07K 1/08 (2006.01) C07K 5/00 (2006.01) C07K 5/083 (2006.01)

Patent

CA 1285698

Abstract of the disclosure: The invention relates to a process for the pre- paration of compounds containing carboxamide groups, in particular peptides, by reaction of compounds which con- tain a carboxyl group, in the presence of dialkylphos- phinic anhydrides, with compounds which contain a free amino group, which comprises maintaining the hydrogen ion concentration of the reaction mixture within a defined range during the reaction by metering in a base and, after the reaction is complete, eliminating, where appropriate, radicals introduced to protect other functional groups.

463073

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