Diastereoisomeric tetrahydropyrido (2,3,-d)pyrimidine...

Details Diastereoisomeric tetrahydropyrido (2,3,-d)pyrimidine... Diastereoisomeric tetrahydropyrido (2,3,-d)pyrimidine...

C - Chemistry, Metallurgy

07

D

260/242.5

C07D 471/04 (2006.01)

Patent

CA 1301155

960-103.1.1 OUS DIASTEREOISOMERIC TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES ABSTRACT The diastereoisomeric forms of N-(4-[2-(2- amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]- pyrimidin-6-yl)ethyl]benzoyl)-L-glutamic acid are antineoplastic agents. The compounds are prepared by separation of the diastereoisomeric form of the correspondingly protected glutamic derivatives and hydrolytic or hydrogenolytic removal of carboxylic acid and/or amino protecting groups.

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