C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/228, 260/297
C07D 213/02 (2006.01) C07D 213/16 (2006.01) C07D 213/26 (2006.01) C07D 213/30 (2006.01) C07D 213/48 (2006.01) C07D 213/55 (2006.01) C07D 213/56 (2006.01) C07D 213/57 (2006.01) C07D 213/80 (2006.01) C07D 213/89 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1257275
ABSTRACT OF THE DISCLOSURE Novel compounds of the formula: Image wherein R2 is an aromatic or heterocyclic group, which may op- tionally be substituted, R2 is a methyl group, a hydroxymethyl group, a nitroxymethyl group, a formyl group, a nitrogen-con- taining five-membered ring-methyl group, an acetal-methyl group, a trialkylsilyloxymethyl group, an alkyl- or aryl-sulfonyloxy- methyl group, an alkyl- or aryl-sulfonylaminocarbonyloxymethyl group, an acyloxymethyl group, an alkoxycarbonyloxymethyl group, a halogenomethyl group, an alkoxymethyl group, an aryloxymethyl group, a cyano group, a carbamoyl group which may optionally be substituted, a carbamoyloxymethyl group which may optionally be substituted, a thiocarbamoyloxymethyl group which may optionally be substituted, and an alkoxycarbonyl group, n is an integer of 1 to 20, and (O?) Image is Image or Image , provided that n is an integer of 9 to 20 when (O?) Image is Image and, at the same time, R is a carboxyl group or an alkoxycarbonyl group, or a pharmacologically acceptable salt thereof, have a selective inhibitory action on bio-synthesis of thromboxane A2(TXA2) and an effect of enhancing the produc- tion of prostaglandin I2(PGI2), and can be used for mammals to prevent and treat of arterial thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in car- diac, cerebral and peripheral circulatory system (e g. cardiac infarction, stroke occlusion of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).
459733
Nishikawa Kohei
Terao Shinji
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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