Pharmacologically active 3-substituted indole derivatives

Details Pharmacologically active 3-substituted indole derivatives Pharmacologically active 3-substituted indole derivatives

C - Chemistry, Metallurgy

07

D

167/231, 260/279

C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 1257597

Indole derivatives Abstract Indole derivatives of the general formula I Image wherein Ind is an indol-3-yl radical which is substituted by a hydroxymethyl or COW group and can additionally be monosubstituted or disubstituted by alkyl, 0-alkyl, OH, F, Cl or Br, W is H, OH, Oalkyl, NH2, NHalkyl or N(alkyl)2, A is -(CH2)n-, CH2-S-CH2CH2-, -CH2-SO-CH2CH2 or -CH2-SO2-CH2CH2, n is 2, 3, 4 or 5, the two radicals Y are each H or together are a C-C bond, one radical Z is Ar, the other radical Z is H and Ar is a phenyl group which is unsubstituted or monosub- stituted or disubstituted by O-alkyl and/or OH or is substituted by a methylenedioxy group, or Ar is a 2- thienyl or 3-thienyl group, the alkyl groups each having 1 - 4 C atoms, wherein, however, when n is 2 or 3, the hydroxymethyl or COW group must be in the 4-, 5-, 6- or 7-position of the indol-3-yl radical, and physiologically acceptable acid addition salts thereof exhibit an action on the central nervous system.

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