.beta.-oxo-.alpha.-carbamoyl-pyrrolepropionitriles

Details .beta.-oxo-.alpha.-carbamoyl-pyrrolepropionitriles .beta.-oxo-.alpha.-carbamoyl-pyrrolepropionitriles

C - Chemistry, Metallurgy

07

D

260/316

C07D 207/337 (2006.01)

Patent

CA 1220214

.beta.-Oxo-.alpha.-carbamoyl-pyrrolepropionitriles Abstract of the Disclosure The invention concerns compounds of the formula I Image (I) wherein Py is 2- or 3-pyrrolyl unsubstituted at the 1-position and optionally substituted at one or more of the remaining three positions by lower alkyl and/or by carboxy or lower carbalkoxy and/or by halogen; R is hydrogen or lower alkyl, and Ph is phenyl, unsubsti- tuted or substituted by one to three identical or different members selected from lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, halogen, trifluoro- methyl, nitro, amino and lower alkanoylamino; salts, especially pharmaceutically acceptable salts thereof; the lower alkyl enol ethers thereof; or the lower alkanoyl enol esters thereof. They can be prepared, for example by removing the group Z from a compound of the formula Image wherein Py, R and Ph have meaning as described above, and Z is a protecting group on the pyrrole nitrogen. These compounds exhibit valuable pharmacological properties including antiinflammatory analgesic, antirheumatic, immuno potentiating and anti- arthritic activity.

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