Temperature sensitive reassortant viruses and a vaccine...

Details Temperature sensitive reassortant viruses and a vaccine... Temperature sensitive reassortant viruses and a vaccine...

A - Human Necessities

61

K

167/130, 195/33

A61K 39/145 (2006.01) C12N 7/00 (2006.01)

Patent

CA 1204069

TEMPERATURE SENSITIVE REASSORTANT VIRUSES AND A VACCINE AGAINST EQUINE INFLUENZA ABSTRACT OF THE DISCLOSURE This invention relates to a method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possess- ing ts lesions and shut off temperatures in the area of 37°-39°C, preferably 37°-38°C. When utilized as a vaccine for equines, these temperature-sensitive recom- binant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.

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