Liposome-gel compositions

Details Liposome-gel compositions Liposome-gel compositions

A - Human Necessities

61

K

167/153, 167/162

A61K 47/00 (2006.01) A61K 9/10 (2006.01) A61K 9/127 (2006.01) B01J 13/02 (2006.01)

Patent

CA 1245156

ABSTRACT Compositions and methods for maintaining reservoirs of bioactive agents by sequestering the reservoir in a gel matrix are described. In particular, liposomes containing an entrapped bioactive agent are sequestered in a gel matrix. The resulting liposome-gel compositions may be used in vivo or in vitro to provide for sustained release of the bioactive agent. The gel matrix inhibits the dispersion and clearance of the sequestered liposomes without interfering with the ability of the liposomes to release the entrapped bioactive agent. Furthermore, the rate of release of the bioactive agent from the liposome-gel compositions may be varied by altering the composition of the liposomes and/or gels.

474034

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