Antibody conjugates

Details Antibody conjugates Antibody conjugates

C - Chemistry, Metallurgy

07

K

167/139, 167/40

C07K 17/08 (2006.01) A61K 39/44 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) G01N 33/532 (2006.01)

Patent

CA 1273570

ABSTRACT OF THE DISCLOSURE An antibody or antibody fragment is modified by chemical linkage to a synthetic poly(amide/urea/thio- urea) which contains a plurality of boron atoms or other functional groups, conferring upon the resultant conjugate desirable properties as a diagnostic and/or therapeutic agent. In a prefered embodiment, boron- containing groups are conjugated to the antibody/ fragment such that the resultant conjugate contains 50-2000 boron atoms, with about 96% Boron-10 isotope content, to produce conjugates useful for neutron- activated radiotherapy of tumors or pathological lesions.

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