C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 167/103
C07K 4/12 (2006.01) A61K 35/14 (2006.01) A61K 39/04 (2006.01) A61K 39/39 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1286989
Abstract Materials are described that nonspecifically amplify the immune response of a person or mammal to antigens to which the person or mammal was previously or is concomitantly exposed. The materials are low M.W. polypeptides and derivatives thereof. Also described are methods and pharmaceutical compositions for the use of the materials in reconstituting immune system function in per- sons suffering from hypoimmune conditions such as AIDS and ARC, and in correcting other immune deficiency imbalances such as that seen in rheumatoid arthritis. Materials of particular interest are a dipeptide containing Tyr-Gly, a tripeptide containing Tyr-Gly-Gly, and derivatives thereof. High pressure liquid chromatography processes are described for the extraction and purification of said materials, from leuko- cyte dialysates derived from human white blood cells. A process for purification of synthetically-derived such material is also described.
525328
Gottlieb A. Arthur
Sim & Mcburney
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