C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/103, 530/7.0
C12N 15/09 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/785 (2006.01) C12P 21/02 (2006.01)
Patent
CA 1341070
The present invention relates to a human SP18 monomer protein-related polypeptide useful in forming a synthetic pulmonary surfactant. The present invention also relates to a method of treating neonatal respiratory distress syndrome comprising administering a therapeutically effective amount of synthetic pulmonary of the present invention. Further contemplated by the present invention is a composition containing human SP18 monomer and human SP18 dimer but no other pulmonary surfactant proteins. A recombinant DNA molecule capable of expressing, without post-translational proteolytic processing, mature human SP18 monomer, and methods of using the recombinant DNA molecule are also contemplated.
587648
Cochrane Charles G.
Revak Susan D.
Fetherstonhaugh & Co.
Scripps Clinic And Research Foundation
The Scripps Research Institute
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