Combination of a long-acting hypnotic agent and a...

Details Combination of a long-acting hypnotic agent and a... Combination of a long-acting hypnotic agent and a...

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 31/15 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2618212

The invention relates to the combination of: a short-acting hypnotic agent which is selected from among a modulator of receptors GABA-A, a benzodiazepine, a phenothiazine, a melatonin derivative and a melatonin receptor agonist; and a long-acting hypnotic agent which is selected from among a modulator of receptors GABA-A, a benzodiazepine, an antagonist of receptors 5HT2A and a calcium ion modulator, for the treatment of sleep disorders. The invention also relates to galenic formulations containing said combination.

L'invention concerne l'association d'un agent hypnotique à durée d'action courte choisi parmi un modulateur des récepteurs GABA-A, une benzodiazépine, une phénothiazine, un dérivé de mélatonine un agoniste des récepteurs à la mélatonine et d'un agent hypnotique à durée d'action longue choisi parmi un modulateur des récepteurs GABA-A, une benzodiazépine, un antagoniste des récepteurs 5HT2A, un modulateur des ions calcium pour traiter les troubles du sommeil. L'invention concerne également des formulations galéniques renfermant cette association.

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