4-pyridyl-and 2,4-pyrimidinyl-substituted pyrrole...

Details 4-pyridyl-and 2,4-pyrimidinyl-substituted pyrrole... 4-pyridyl-and 2,4-pyrimidinyl-substituted pyrrole...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/429 (2006.01) A61K 31/437 (2006.01) A61K 31/542 (2006.01) A61P 37/00 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2398111

The present invention relates to 4-pyridyl- und 2,4- pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy, of the formula 1 Image in which the variables have the meanings indicated in the de- scription. The compounds according to the invention have immunomodulating and/or cytokine release-inhibiting action and are therefore utilizable for the treatment of disorders which are connected with a disturbance of the immune system.

La présente invention concerne des dérivés de pyrrole 4-pyridyl- et 2,4-pyrimidinyl-substitués et leur utilisation en pharmacie. Ces dérivés sont de formule (1), dans laquelle les variables ont les significations données dans la description de cette invention. Les composés selon cette invention possèdent un pouvoir d'immunomodulation et/ou d'inhibition de libération de cytokine et peuvent par conséquent être utilisés dans le traitement de maladies associées à un trouble du système immunitaire.

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