Once-a-day oxycodone formulations

Details Once-a-day oxycodone formulations Once-a-day oxycodone formulations

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 9/30 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2474904

The invention is directed to sustained release formulations containing oxycodone or a pharmaceutically acceptable salt thereof which provide a mean C24/Cmax oxycodoen ratio of 0.6 to 1.0 or 0.7 to 1 after oral administration at steady state to patients and methods thereof.

La présente invention concerne des formulations à libération prolongée, qui contiennent de l'oxycodone ou un sel de celle-ci, acceptable d'un point de vue pharmaceutique, et qui fournissent un rapport d'oxycodone C¿24?/C¿max? moyen allant de 0,6 à 1,0 ou de 0,7 à 1, après une administration par voie orale à des patients à l'état stationnaire. La présente invention concerne également des procédés pour mettre en oeuvre ces formulations.

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