Chimeric allograft tolerance induction, monitoring and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A01N 63/00 (2006.01) A61K 31/436 (2006.01) A61K 31/445 (2006.01) A61K 38/13 (2006.01) A61K 39/00 (2006.01) A61K 45/06 (2006.01) C07K 16/28 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2486620

A method is provided for inducing donor-specific tolerance and/or mixed donor- recipient chimerism in an allograft transplant recipient, by administering to a recipient of an allograft a therapeutically effective amount of an immunosuppressive agent that depletes T cells; administering to the recipient of the allograft a therapeutically effective amount of anti-.alpha..beta. T cell receptor antibodies; implanting an allograft from an allograft donor into the recipient; and implanting a therapeutically effective amount of bone marrow cells from the allograft donor into the allograft recipient.

L'invention concerne un procédé destiné à induire une tolérance spécifique au donneur et/ou à un chimérisme mélangé donneur-receveur chez le receveur d'une allogreffe. Ledit procédé consiste à : administrer au receveur d'une allogreffe une quantité efficace thérapeutiquement d'un agent immunosuppresseur qui vise à épuiser les lymphocytes T ; administrer au receveur de l'allogreffe une quantité efficace thérapeutiquement d'anticorps de l'anti-récepteur de lymphocytes T .alpha.-.beta. ; implanter une allogreffe du donneur de l'allogreffe chez le receveur ; et à implanter une quantité efficace thérapeutiquement de cellules de moelle osseuse du donneur de l'allogreffe chez le receveur de l'allogreffe.

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