Regulation of osteoclast formation by inhibition of...

Details Regulation of osteoclast formation by inhibition of... Regulation of osteoclast formation by inhibition of...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/475 (2006.01) C07K 16/00 (2006.01) C07K 16/22 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2301979

The present invention provides an inhibitor of osteoblastic stem cell factor binding and/or activity, for example, an antibody or an antisense oligonucleotide. Also provided are pharmaceutical compositions comprising these inhibitors of osteoblastic stem cell factor binding and/or activity. Further provided is a method of regulating the activity of osteoclasts, comprising the step of: inhibiting the binding and/or activity of osteoblastic stem cell factor.

La présente invention concerne un inhibiteur de liaison et/ou d'activité du facteur de cellules souches ostéoblastiques, par exemple un anticorps ou un oligonucléotide antisens. La présente invention concerne également des compositions pharmaceutiques comprenant ces inhibiteurs de liaison et/ou d'activité du facteur de cellules souches ostéoblastiques. La présente invention concerne, en outre, un procédé de régulation de l'activité des ostéoclastes consistant à inhiber la liaison et/ou l'activité du facteur de cellules souches ostéoblastiques.

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