C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/60 (2006.01) A61K 31/34 (2006.01)
Patent
CA 2269035
This invention provides compounds of formula (I) having structure (1) wherein: R1 is hydrogen, halogen, alkyl, alkoxy, fluoroalkoxy, trifluoromethyl, alkylthio, or SCF3; R2 and R3 are each independently hydrogen or alkyl, or R2 and R3 may be taken together to form a saturated cycloalkyl ring; and R4, R5, R6, R7 and R8 are each independently hydrogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halogen, fluoroalkoxy, CF3 or SCF3 which are useful in the treatment of arthritic disorders, colorectal cancer, and Alzheimer's disease.
La présente invention concerne des composés représentés par la structure (1) de la formule générale (I). Dans cette formule, R<1> est hydrogène, halogène, alkyl, alcoxy, fluoroalcoxy, trifluorométhyl, alkylthio ou SCF3; R<2> et R<3> sont chacun indépendamment hydrogène ou alkyl, ou bien R<2> et R<3> peuvent, ensemble, former un cycle cycloalkyl saturé. Enfin, R<4>, R<5>, R<6>, R<7> et R<8> sont chacun indépendamment hydrogène, alkyl, alcoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halogène, fluoroalcoxy, CF3 ou SCF3. Ces composés conviennent particulièrement au traitement de troubles arthritiques, du cancer colorectal et de la maladie d'Alzheimer.
American Home Products Corporation
Ridout & Maybee Llp
LandOfFree
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