Process for the isolation and purification of taxol and...

Details Process for the isolation and purification of taxol and... Process for the isolation and purification of taxol and...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C12P 15/00 (2006.01) C12P 17/02 (2006.01)

Patent

CA 2126698

ABSTRACT OF THE DISCLOSURE A process for the separation of taxanes, particularly taxol, cephalomannine, baccatin III and deacetylbaccatin III, from ornamental yew tissue is described. The process involves a specific solvent mixture of water and 50 to 95 percent by volume methanol, ethanol or acetone and treatment of the resulting extract using activated carbon, preferably charcoal. The taxanes are preferably separated from the crude extract by a normal phase chromatographic step which preferably is through vacuum and then medium pressure column chromatographic separation, using inexpensive silica gel as an absorbent. The silica gel is regenerated by heating in a furnace above about 500°C to remove adsorbed organic materials.

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