Process for the preparation of thalidomide

Details Process for the preparation of thalidomide Process for the preparation of thalidomide

C - Chemistry, Metallurgy

07

D

C07D 209/48 (2006.01) A61K 31/4035 (2006.01) A61K 31/4178 (2006.01) A61K 31/437 (2006.01) C07C 229/34 (2006.01) C07D 209/46 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2531868

The present invention relates to compounds which are useful for reducing levels of TNF.alpha. in a mammal. Examples of compounds include those of formula: See formula 1 wherein, for example, R7 is a cyclic alkyl, a substituted phenyl, etc ...; n is 1 and R12 is an alkoxy, a disubstituted amino, etc ...; those of formula: See formula 2 wherein, for example, Z is See formula 3 n is 1, 2 or 3; R1 is a divalent residue of 3,4-pyridine, pyrrolidine, etc ...; R2 is -CO- or -SO2-; R3 is a substituted phenyl, pyridyl, etc ...; and R4 is alanyl, argynyl, etc ...; or those of formula: Image wherein, for example, an optionally substituted o-phenylene, a divalent residue of pyridine, etc ...; R6 is -CO-, -CH2- or -SO2-; R7 is pyridyl, substituted phenyl etc ...; and R12 is -OH, alkoxy, etc ...;

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