A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/365 (2006.01) A61K 31/194 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2525367
Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
L'invention concerne des méthodes consistant à traiter des individus chez lesquels un cancer a été diagnostiqué, par l'administration d'un inhibiteur de l'ATP-citrate lyase et/ou d'un inhibiteur du transporteur de tricarboxylate. L'invention porte également sur des méthodes permettant d'induire l'apoptose des cellules cancéreuses au moyen d'un inhibiteur de l'ATP-citrate lyase et/ou d'un inhibiteur du transporteur de tricarboxylate. L'invention se rapporte en outre à des méthodes permettant de traiter un individu atteint d'un cancer, les étapes de ces méthodes comprenant l'identification d'un cancer présentant un taux de glycolyse aérobie élevé, et l'administration d'un inhibiteur de l'ATP-citrate lyase et/ou d'un inhibiteur du transporteur de tricarboxylate. Enfin, l'invention concerne des méthodes consistant à traiter des individus atteints d'un cancer par l'administration de composés inhibant l'expression de l'ATP-citrate lyase ou du transporteur de tricarboxylate, ainsi que des méthodes permettant d'identifier un composé présentant une activité anticancéreuse.
Bauer Daniel
Hatzivassiliou Georgia
Thompson Craig B.
The Trustees Of The University Of Pennsylvania
Torys Llp
LandOfFree
Use of citrate lyase inhibitors and tricarboxylate... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of citrate lyase inhibitors and tricarboxylate..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of citrate lyase inhibitors and tricarboxylate... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1344417