A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2540695
The present invention is concerned with delivering a pharmaceutical composition to the brain of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytised or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the brain.
La présente invention concerne l'administration d'une composition pharmaceutique au cerveau d'un sujet mammifère dans le but de traiter des pathologies et des troubles du cerveau. Cette méthode passe par les opérations suivantes : (i) utilisation de la composition pharmaceutique sous forme de dispersion dont les particules ont une taille moyenne comprise entre 150 nm et 100 nm environ ; et (ii) administration de la dispersion au sujet mammifère pour administration au cerveau d'une partie de la composition pharmaceutique par des cellules capables d'atteindre le cerveau. La dispersion de la composition pharmaceutique en particules, par exemple, peut être phagocytée ou adsorbée par des cellules avant ou après administration au sujet mammifère. Cette dispersion peut être administrée au système nerveux central ou au système vasculaire. Après administration, les cellules chargées transportent la composition pharmaceutique particulaire dans le cerveau.
Gendelman Howard E.
Kipp James E.
Rabinow Barrett E.
Baxter Healthcare S.a.
Baxter International Inc.
Board Of Regents Of The University Of Nebraska
Sim & Mcburney
LandOfFree
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