Isolation and structure of spongistatin 1

Details Isolation and structure of spongistatin 1 Isolation and structure of spongistatin 1

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07D 493/22 (2006.01) C12P 17/18 (2006.01) C12P 19/44 (2006.01)

Patent

CA 2113656

An Eastern Indian Ocean marine sponge in the genus onaia was located in the Republic of the Maldives and found to contain a structurally unprecedented macrocyclic lactone named spongistatin 1. The new perhydropyran-containing structure, as shown below, was found to be remarkably potent and specific, log molar TCI50 to < -10, against twenty human cancer cell lines in the U.S. National Cancer Institute s panel of sixty. Image

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