1,2,4-benzothiadiazine derivatives, their preparation and use

Details 1,2,4-benzothiadiazine derivatives, their preparation and use 1,2,4-benzothiadiazine derivatives, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 285/24 (2006.01) A61K 31/54 (2006.01) A61K 31/5415 (2006.01) A61K 31/55 (2006.01) C07D 417/12 (2006.01) C07D 453/02 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2258100

1,2,4-Benzothiadiazine derivatives represented by formula (I) wherein D, R1, R2, R3, R4, R5, R12, R13, R14, R15 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.

Dérivés de 1,2,4-benzothiadiazine représentés par la formule (I) dans laquelle D, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?12¿, R?13¿, R?14¿, R?15¿ sont définis dans le descriptif, leurs compositions et procédés de préparation de ces composés. Ces composés sont utiles dans le traitement de maladies du système nerveux central, du système cardio-vasculaire, du système pulmonaire, du système gastro-intestinal et du système endocrinien.

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