Tetracyclic amino and carboxamido compounds and methods of...

A - Human Necessities – 61 – K

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A61K 31/473 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07D 221/18 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2598647

The present invention relates to Tetracyclic Amino Compounds and Tetracyclic Carboxamido Compounds, compositions comprising an effective amount of a Tetracyclic Amino Compound or a Tetracyclic Carboxamido Compound and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, Parkinson's disease, renal failure, a vascular disease, a cardiovascular disease, or cancer, comprising administering to a subject in need thereof an effective amount of a Tetracyclic Amino Compound or a Tetracyclic Carboxamido Compound.

L'invention se rapporte à des composés amino tetracycliques et des composés carboxamido tetracycliques, à des compositions contenant une quantité efficace d'un composé amino tetracycliques ou d'un composé carboxamido tetracyclique, ainsi qu'à des procédés de traitement ou de prévention d'une maladie inflammatoire, d'une lésion de reperfusion, de diabètes, d'une complication diabétique, d'une lésion de réoxygénation due à une transplantation d'organe, d'une condition ischémique, de la maladie de Parkinson, d'une insuffisance rénale, d'une maladie vasculaire, ou d'un cancer, consistant à administrer à un patient qui en a besoin une quantité efficace d'un composé amino tetracyclique ou d'un composé carboxamido tetracyclique.

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