Use of c-kit inhibitors for treating fibrosis

Details Use of c-kit inhibitors for treating fibrosis Use of c-kit inhibitors for treating fibrosis

A - Human Necessities

61

K

A61K 31/497 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/4433 (2006.01) A61K 31/4436 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/5355 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2564574

The present invention relates to a method for treating fibrosis and related disorders comprising administering a compound capable of depleting mast cell or a compound inhibiting mast cells degranulation, to a human in need of such treatment. Such compounds can be chosen from c-kit inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

L'invention concerne une méthode de traitement de la fibrose et des troubles associés. Cette méthode consiste à administrer à un être humain nécessitant ce traitement un composé capable d'épuiser les mastocytes ou un composé inhibant la dégranulation des mastocytes. Ces composés peuvent être choisis dans le groupe constitué d'inhibiteurs de c-kit, notamment les inhibiteurs de c-kit non toxiques, sélectifs et puissants. De préférence, cet inhibiteur n'est pas capable de stimuler la mort des cellules dépendant de IL-3 cultivées en présence de IL-3.

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