Heterocyclic vinylethers against neurological disorders

Details Heterocyclic vinylethers against neurological disorders Heterocyclic vinylethers against neurological disorders

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/41 (2006.01) A61K 31/4174 (2006.01) A61K 31/4196 (2006.01) A61P 25/00 (2006.01) C07D 257/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2297732

The invention is concerned with the use of compounds of general formula (I), wherein R signifies halogen or lower alkyl; n signifies 0-3; R1 signifies lower alkyl; cycloalkyl; benzyl optionally substituted by hydroxy, halogen, lower alkoxy or lower alkyl; benzoyl optionally substituted by amino, lower alkylamino or di-lower alkylamino; acetyl or cycloalkyl-carbonyl; and (A) signifies an aromatic 5-membered residue which is bonded via a N-atom and which contains further 1-3 N atoms in addition to the linking N atom, as well as their pharmaceutically acceptable salts as therapeutically active substances, especially for the control or prevention of acute and/or chronic neurological disorders.

L'invention concerne l'utilisation de composés de formule générale (I), ainsi que de leurs sels pharmaceutiquement acceptables, comme substances actives thérapeutiques, surtout pour maîtriser ou prévenir des troubles neurologiques aigus et/ou chroniques. Dans la formule, R désigne un halogène ou alkyle inférieur; n vaut 0 à 3; R<1> désigne un alkyle inférieur, cycloalkyle, benzyle le cas échéant substitué par hydroxyle, halogène, alcoxy inférieur ou alkyle inférieur, benzoyle le cas échéant substitué par amino, alkylamine inférieure ou dialkylamine inférieure, acétyle ou cycloalkyle-carbonyle; et (A) désigne un radical aromatique à 5 maillons relié par un atome de N et qui contient, outre l'atome de N de liaison, 1 à 3 atomes de N.

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