Tumour suppressor gene dbccr1 at 9q32-33

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 31/70 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) C07K 16/22 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2288235

The application relates to the identification of a tumour suppressor locus at 9q32-33, and a gene within this region is disclosed. The gene is called "DBCCR1" for <u>D</u>eleted in <u>B</u>ladder <u>C</u>ancer <u>C</u>hromosome <u>R</u>egion candidate 1. The application further relates to uses of these findings, in particular in the diagnostic, prophylactic and therapeutic treatment of cancer, especially bladder cancer. In particular, some forms of cancer are linked to hypermethylation based silencing of the DBCCR1 promoter or gene.

L'invention concerne l'identification d'un locus suppresseur de tumeur situé dans la région 9q32-33 et d'un gène se trouvant dans cette région. Ce gène est dénommé "DBCCR1", équivalent de candidat n·1 correspondant à la région du chromosome qui est supprimée lors d'un cancer de la vessie. L'invention se rapporte en outre aux utilisations de cette découverte, en particulier dans le diagnostic, le traitement prophylactique et thérapeutique du cancer et en particulier du cancer de la vessie. Certaines formes de cancer en particulier sont liées au blocage du promoteur du DBCCR1 ou de ce gène, blocage provoqué par l'hyperméthylation.

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