C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/42 (2006.01) C07K 16/24 (2006.01) C12N 15/19 (2006.01) C12N 15/66 (2006.01)
Patent
CA 2341029
In accordance with the present invention, there are provided methods for the extension of serum half-lives of proteinaceous molecules, particularly antibody molecules, and compositions of molecules modified in accordance with the methods of the invention. In accordance with a first aspect of the present invention, there is provided a method of modifying the half-life of an antibody through providing an antibody containing an FcRn binding domain or the genes encoding such antibody and physically linking the antibody or the antibody as encoded to a second FcRn binding domain. In accordance with a second aspect of the present invention, there is provided a molecule that contains at least two distinct FcRn binding moieties.
La présente invention concerne des procédés d'extension des demi-vies sériques de molécules protéiniques, particulièrement de molécules d'anticorps, cette invention concernant également des compositions de molécules modifiées selon les procédés de l'invention. Un premier aspect de l'invention concerne un procédé de modification de la demi-vie d'un anticorps grâce à un anticorps comprenant un domaine de liaison FcRn, ou aux gènes codant un tel anticorps fixant physiquement cet anticorps ou l'anticorps ainsi codé sur un second domaine de liaison FcRn. Un second aspect de l'invention concerne une molécule renfermant au moins deux fractions de liaison FcRn distinctes.
Foord Orit
Gallo Michael
Junghans Richard
Abgenix Inc.
Smart & Biggar
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