Improvements in or relating to contrast agents

A - Human Necessities – 61 – K

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A61K 49/00 (2006.01) A61K 47/26 (2006.01) A61K 47/42 (2006.01) A61K 49/22 (2006.01) B01J 13/02 (2006.01) B01J 13/20 (2006.01) C07C 69/96 (2006.01)

Patent

CA 2107107

Ultrasound contrast agents comprising microbubbles of gas or a gas precursor encapsulated in a protein shell, e.g. of hu- man serum albumin, the protein being crosslinked with biodegradable crosslinking groups, exhibit stability in vivo upon adminis- tration so as to permit altrasound visualisation while allowing rapid subsequent elimination from the system.

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