C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 1/14 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2308112
The present invention relates to a novel Caspase-14 protein (also called ERICE) which is a novel effector of apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human Caspase-14 protein. Caspase-14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Caspase-14 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
La présente invention concerne une nouvelle protéine Caspase-14 (également appelée ERICE) laquelle est un nouvel effecteur de l'apoptose. L'invention concerne notamment des molécules d'acide nucléique isolées codant la protéine Caspase-14 humaine. De plus, l'invention concerne des polypeptides de Caspase-14 de même que des vecteurs, des cellules hôtes et des méthodes de recombinaison permettant leur production. En outre, l'invention concerne des méthodes de criblage pour identifier des agonistes et des antagonistes de l'activité Caspase-14, de même que des méthodes thérapeutiques de traitement de maladies et de troubles associés à l'apoptose.
Ni Jian
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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