Use of glp-1 analogues for the treatment of disorders...

Details Use of glp-1 analogues for the treatment of disorders... Use of glp-1 analogues for the treatment of disorders...

A - Human Necessities

61

K

A61K 38/26 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2698780

The present invention relates to a peptide analogue of glucagon-like peptide-1 (7-36), which is useful to prophylactically prevent, improve, or reverse the diminished cognitive function associated with these types of disorders, by increasing (or sustaining) the LTP of synaptic transmission. Moreover, sustaining LTP may find utility in the prophylaxis of neurological disease by delaying the onset of impaired cognitive processes, and could serve as a treatment, not only for the diminished cognitive function caused by neurodegeneration, but also for the dysfunctional cognitive processes associated with trauma or age.

L'invention concerne un analogue peptidique du peptide du type glucagon 1 (7-36), qui est utilisé de manière prophylactique pour prévenir, améliorer ou inverser l'évolution d'une fonction cognitive diminuée associée à ce type de troubles, en augmentant (ou en maintenant) la potentialisation à long terme de la transmission synaptique. Il peut en outre être utile de maintenir la potentialisation à long terme dans la prophylaxie de maladies neurologiques en retardant l'apparition de processus cognitifs altérés, et dans le traitement, non seulement d'une fonction cognitive diminuée en raison d'une neurodégénérscence, mais également de processus cognitifs dysfonctionnels associés à un traumatisme ou à l'âge.

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