The use of substituted azetidinone compounds for the...

A - Human Necessities – 61 – K

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A61K 31/397 (2006.01) A61K 31/7042 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2434430

The present invention is directed to the use of sterol absorption inhibiting compounds, pharmaceutical compositions thereof, therapeutic combinations and their use in combination with other lipid lowering agents to treat or prevent sitosterolemia and/or to lower the concentration of sterol(s) other than cholesterol in plasma or tissue of a mammal. Methods of treating or preventing vascular disease and coronary events also are provided.

L'invention concerne des composés inhibiteurs de l'absorption de stérols, des compositions pharmaceutiques, des combinaisons thérapeutiques, ainsi que leur utilisation en association à d'autres agents hypolipidémiants pour traiter ou prévenir la sitostérolémie et/ou réduire la concentration de stérol(s) autres que le cholestérol dans le plasma ou les tissus d'un mammifère. Par ailleurs, l'invention concerne des méthodes de traitement ou de prévention des maladies vasculaires et des accidents vasculaires.

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