Method for enhancing antibody transport through capillary...

Details Method for enhancing antibody transport through capillary... Method for enhancing antibody transport through capillary...

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 47/48 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2077670

A method for increasing the transcytosis of an antibody across the microvascular barrier and into the interstitial fluid of organs is disclosed. The method consists of cationizing the antibody with a cationizing agent to increase the isoelectric point of the antibody by between about 1 to about 7 to produce a cationized antibody having an isoelectric point which is less than about 11.5. The increased rate of transport across the microvascular barrier of organs makes such canonized antibodies useful for both therapeutic and diagnostic purposes.

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