Anti-alpha v beta 6 antibodies and uses thereof

C - Chemistry – Metallurgy – 12 – P

Patent

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Details

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) C12P 21/04 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2614183

The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin av~6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin av~6.

L'invention se rapporte aux domaines de la biologie cellulaire, de l'immunologie et de l'oncologie. Spécifiquement, l'invention concerne des anticorps humanisés reconnaissant des intégrines v 6, comprenant une région variable, d'origine non humaine, et au moins une portion d'une immunoglobuline d'origine humaine. L'invention concerne également des procédés pour leur préparation, des compositions pharmaceutiques les renfermant, ainsi que des procédés de traitement de diverses maladies par administration d'anticorps humanisés anti-v 6. L'invention concerne en outre l'identification de l'expression différentielle de l'intégrine av.beta.6 sur les surfaces de cellules et de tissus tumoraux, l'utilisation de cette expression différentielle dans la détermination du potentiel métastatique des cellules tumorales, et des procédés de diagnostic et de traitement/prévention des métastases tumorales et de l'élimination des cellules tumorales métastatiques résiduelles au moyen de ligands, en particulier d'anticorps se liant à l'intégrine av.beta.6.

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