Vaccines comprising aluminium adjuvants and histidine

Details Vaccines comprising aluminium adjuvants and histidine Vaccines comprising aluminium adjuvants and histidine

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2452720

To improve the stability of vaccines comprising aluminium salt(s), the invention uses the amino acid histidine. This can improve pH stability and adjuvant adsorption and can be reduce antigen hydrolysis. Histidine is preferably presen during adsorption to the aluminium salt(s). The antigen in the vaccine may be a protein or a saccharide and is preferably from N. meningitidis.

Pour améliorer la stabilité de vaccins comprenant du/des sel(s) d'aluminium, l'invention utilise de l'amino-acide histidine. Ceci peut améliorer la stabilité du pH et l'absorption d'adjuvant et peut réduire l'hydrolyse d'antigènes. L'histidine est, de préférence, présente durant l'absorption par le/les sel(s) d'aluminium. L'antigène contenu dans le vaccin peut être une protéine ou un saccharide et est, de préférence, <i>N. meningitidis</i>.

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