Use of a peptide or antibody in the manufacture of a...

Details Use of a peptide or antibody in the manufacture of a... Use of a peptide or antibody in the manufacture of a...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/71 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2322592

Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.

Cette invention, qui a trait à des méthodes de traitement d'une personne atteinte d'une tumeur liée à la protéine erbB, concerne également des méthodes de prévention de ladite tumeur. Cette méthode consiste à administrer à la personne une molécule d'acide nucléique codant une protéine qui subit une dimérisation en présence de la protéine erbB et qui fait montre d'insuffisance en matière d'activité tyrosine kinase. L'invention porte également sur des compositions pharmaceutiques renfermant ces molécules d'acide nucléique.

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