Localized non-invasive biological modulation system

Details Localized non-invasive biological modulation system Localized non-invasive biological modulation system

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 9/00 (2006.01) A61K 41/00 (2006.01)

Patent

CA 2481020

The present invention provides methods for non-invasive localized delivery of biologically active molecules, comprising packaging a molecule(s) of interest inside a thermosensitive particle, administering said particles to a subject, and inducing localized release of said molecules from said particles using a focused heat source. The thermosensitive particles may be thermosensitive polymer nanoparticles or thermosensitive liposomes. The particles may be delivered to a subject by any technique, including infusion. The molecules may be released from the particles using any method which induces localized hyperthermia, including focused ultrasound.

L'invention concerne des procédés d'apport localisé non effractif de molécules biologiquement actives, qui comportent les étapes consistant à : enfermer une ou des molécule(s) voulue(s) à l'intérieur d'une particule thermosensible ; administrer ces particules à un sujet ; et induire, à l'aide d'une source de chaleur concentrée, une libération localisée desdites molécules contenues dans les particules. Les particules thermosensibles peuvent être des nanoparticules polymères thermosensibles ou des liposomes thermosensibles. Ces particules peuvent être administrées à un sujet par n'importe quelle technique, y compris par perfusion. Les molécules peuvent être libérées des particules à l'aide de n'importe quel procédé induisant une hyperthermie localisée, y compris les ultrasons focalisés.

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