Method of producing porous delivery devices

Details Method of producing porous delivery devices Method of producing porous delivery devices

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 31/045 (2006.01) A61K 31/41 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2131089

An efficient method for making high strength, highly porous, fast dissolving delivery devices. The method comprises mixing a formulation comprising menthol, a water-soluble, menthol-soluble polymer, and an active agent at a temperature such that the menthol is substantially molten. The formulation is disposed in a mold, solidified and the menthol is sublimed from the solidified molded formulation. Preferably, the solidification occurs at a temperature sufficient to provide a substantially amorphous menthol structure.

Méthode efficace pour fabriquer des dispositifs de libération haute résistance, hautement poreux et à dissolution rapide. La méthode comprend le mélange de la formulation comprenant du menthol, un polymère soluble dans l'eau et le menthol ainsi qu'un agent actif à une température telle que le menthol est substantiellement fondu. La formulation est placée dans un moule, solidifiée et le menthol est sublimé de la formulation fondue solidifiée. De préférence, la solidification survient à une température suffisante pour donner au menthol une structure substantiellement amorphe.

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