Genetic variants on chr 5p12 and 10q26 as markers for use in...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2688312

The invention pertains to certain genetic variants on Chr5p12 and Chr10q26 as susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased and/or decreased susceptibility to breast cancer, methods of predicting response to therapy and methods of predicting prognosis using such variants are described. The invention further relates to kits useful in the methods of the invention.

L'invention porte sur certaines variantes génétiques sur les Chr5p12 et Chr10q26 en tant que variantes de susceptibilité du cancer du sein. L'invention porte également sur des procédés de gestion de maladie, comprenant le diagnostic d'une susceptibilité accrue et/ou réduite au cancer du sein, sur des procédés de prédiction d'une réponse à une thérapie et sur des procédés de prédiction d'un pronostic à l'aide de telles variantes. L'invention porte en outre sur des coffrets utiles dans les procédés de l'invention.

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