Selective adenosine receptor compounds

Details Selective adenosine receptor compounds Selective adenosine receptor compounds

C - Chemistry, Metallurgy

07

D

167/202, 167/220

C07D 487/14 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2013381

Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo. Pharmaceutical preparations of the subject compounds of FORMULA I (see formula I) can be prepared on the basis of the selective binding activity of the compounds disclosed herein which can be expected to enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.

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