Assessment of cervical cells

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) G01N 33/554 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2262531

A method of determining abnormality in a tissue sample containing cells of the cervix, the method comprising determining binding of specific binding substances to the sample and comparing the binding with the pattern of binding of said specific binding substances to a normal cervical cell sample. The specific binding substances may be antibodies. Hybridomas which produce suitable antibodies have been deposited at the European Collection of Animal Cell Cultures (ECACC), Centre for Applied Microbiology & Research, Salisbury, Wiltshire SP4 0JG, United Kingdom on 6 February 1995 under the accession numbers ECACC 95020718, 95020716, 95020720, 95020717 and 95020719.

Cette invention concerne un procédé visant à établir une anormalité dans un échantillon tissulaire contenant des cellules du col utérin. Ledit procédé consiste à évaluer la liaison de substances liantes spécifiques à l'échantillon et à comparer la liaison desdites substances liantes spécifiques à un échantillon de cellules normales du col utérin. Ces substances spécifiques liantes peuvent être des anticorps. Les hybridomes qui produisent des anticorps appropriés ont été déposés auprès de la souchothèque européenne des cultures de cellules animales (ECACC pour "European Collection of Animal Cell Cultures"), au centre de recherche et de microbiologie appliquée, à Salisbury, Wiltshire SP4 0JG, Royaume-Uni, le 6 février 1995 sous les numéros d'ordre ECACC 95020718, 95020716, 95020720, 95020717 et 95020719.

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