High concentration antibody and protein formulations

Details High concentration antibody and protein formulations High concentration antibody and protein formulations

A - Human Necessities

61

K

A61K 47/18 (2006.01) A61K 9/08 (2006.01) A61K 39/395 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2718356

The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration. The application further describes articles of manufacture containing such formulations and method for using them to treat disorders treatable by the formulated antibody or protein. The formulations comprise arginine-HC1, histidine and polysorbate.

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