Beta-carboline sulphonylurea derivatives as ep4 receptor...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2737618

The invention is directed to .beta.-carboline sulphonylurea derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, inflammation, osteoarthritis, and rheumatoid arthritis. Pharmaceutical compositions and methods of use are also included.

Linvention concerne des dérivés de ß-carboline sulfonylurée en tant quantagonistes du récepteur dEP4, qui sont utiles pour le traitement de maladies ou troubles médiés par EP4, tels que la douleur aiguë et chronique, linflammation, lostéoarthrite et la polyarthrite rhumatoïde. Linvention concerne également des compositions pharmaceutiques et des procédés dutilisation.

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