Podophyllotoxin derivatives

Details Podophyllotoxin derivatives Podophyllotoxin derivatives

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/365 (2006.01) A61K 31/683 (2006.01) A61P 35/00 (2006.01) C07D 493/04 (2006.01) C07D 519/00 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2530037

4-0 esters of podophyllotoxin and 4~-demethylepipodophyllotoxin are provided. The compounds are 4-0 esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4~-demethylepipodophyllotoxin. The compounds are useful for treating cancer.

L'invention concerne des 4-O esters de podophyllotoxine et de 4'-déméthylépipodophyllotoxine. Les composés sont des 4-O esters d'un acide alcanoïque ou d'un acide alcanoïque substitué et de podophyllotoxine et de 4'-déméthylépipodophyllotoxine. Ces composés sont utiles dans le traitement du cancer.

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