Novel tricyclic compounds and drug compositions containing...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/88 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) C07C 275/32 (2006.01) C07C 307/10 (2006.01) C07C 311/08 (2006.01) C07C 311/13 (2006.01) C07C 311/37 (2006.01) C07D 307/91 (2006.01) C07D 333/76 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2242351

Compounds represented by general formula (I) or salts thereof, a process for producing the same, and intermediates therefor, wherein R represents hydrogen or methyl; R1 represents hydrogen, halogeno, hydroxy, benzyloxy, amino, or hydroxymethyl; R2 represents hydrogen, hydroxymethyl, NHR3, SO2NR4R4, or nitro; R6 represents hydrogen or lower alkyl; and X represents nitrogen, oxygen, sulfur, or methylene, provided that when X represents nitrogen, oxygen, or sulfur, then R9 represents hydrogen, one of R7 and R8 represents hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy, and when X represents methylene, then R7 and R8 each represents hydrogen and R9 represents hydrogen, amino, etc. They have a .beta.-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc.

Cette invention concerne des composés représentés par la formule générale (I) ou des sels de ces composés, un procédé de préparation de ces composés et des intermédiaires associés à ces composés. Dans la formule (I), R est hydrogène ou méthyle, R?1¿ est hydrogène, halogéno, hydroxy, benzyloxy, amino ou hydroxyméthyle, R?2¿ est hydrogène, hydroxyméthyle, NHR?3¿, SO¿2?NR?4¿R?4¿ ou nitro, R?6¿ est hydrogène ou alkyle inférieur et X est azote, oxygène, soufre ou méthylène, à condition que lorsque X est azote, oxygène ou soufre, alors R?9¿ représente hydrogène, l'un des deux éléments R?7¿ et R?8¿ est hydrogène, l'autre étant par conséquent hydrogène, amino, acétylamino ou hydroxy et lorsque X est méthylène, alors R?7¿ et R?8¿ sont chacun hydrogène et R?9¿ est hydrogène, amino, etc. Ces composés ont une activité d'agoniste de récepteur d'adrénaline .beta.-3 et ils sont utiles en tant que médicaments pour le traitement et la prévention du diabète, de l'obésité, de l'hyperlipémie etc.

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