Herpes simplex virus-1 deletion variants and vaccines thereof

Details Herpes simplex virus-1 deletion variants and vaccines thereof Herpes simplex virus-1 deletion variants and vaccines thereof

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61K 39/245 (2006.01) A61K 39/295 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2101639

Novel Herpes simplex viruses and vaccines based on such novel HSV-1 strains are described. In particular, viruses having a deletion in the terminal portion of R L are provided. The virus can be further modified to express heterologous antigens and also engineered to overproduce HSV Light particles. This is achieved by incorporating a is mutation into the UL26 gene.

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