C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/68 (2006.01)
Patent
CA 2747678
The present invention relates to soluble CD47 binding polypeptides, for use as a medicament, in particular for the prevention or treatment of autoimmune and inflammatory disorders, for example allergic asthma and inflammatory bowel diseases. The Invention more specifically relates to a soluble CD47 binding polypeptide for use as a medicament, comprising an extracellu-lar domain of SIRP.alpha. (CD172a) or functional derivatives which bind to human CD47.
La présente invention concerne des polypeptides de liaison à CD47 solubles pouvant être employés en tant que médicaments, en particulier dans la prévention ou le traitement de troubles auto-immuns et inflammatoires, par exemple de l'asthme allergique et des affections abdominales inflammatoires. La présente invention concerne plus spécifiquement un polypeptide de liaison à CD47 soluble pouvant être employé en tant que médicament, comprenant un domaine extracellulaire de SIRPa (CD172a) ou des dérivés fonctionnels se liant au CD47 humain.
Raymond Marianne
Sarfati Marie
Welzenbach Karl
Woisetschlaeger Maximilian
Fetherstonhaugh & Co.
Novartis Ag
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