Intra-vascular kidney gene therapy with plasmid encoding bmp-7

Details Intra-vascular kidney gene therapy with plasmid encoding bmp-7 Intra-vascular kidney gene therapy with plasmid encoding bmp-7

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2669669

The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.

L'invention porte sur des vecteurs recombinants codant le polypeptide BMP-7 dans des cellules hôtes et sur des compositions pharmaceutiques renfermant lesdits vecteurs recombinants. L'invention se rapporte également à des procédés de prévention et/ou traitement de l'insuffisance rénale aiguë et chronique chez les mammifères, de préférence chez les êtres humains, les chiens et les chats, par l'administration rénale intravasculaire des vecteurs recombinants et des compositions pharmaceutiques de l'invention.

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