Aryl-and arylamino-substituted heterocycles as corticotropin...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/42 (2006.01) A61K 31/505 (2006.01) C07D 251/22 (2006.01) C07D 401/04 (2006.01) C07D 473/00 (2006.01) C07D 473/40 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2296014

Corticotropin releasing factor (CRF) antagonists of formula (I), and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart- related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.

L'invention concerne des antagonistes du facteur libérateur de corticotropine représentés par la formule (I), et leur utilisation pour traiter les troubles psychiatriques, les affections neurologiques, les troubles liés à l'anxiété, les états de stress post-traumatiques, la paralysie supranucléaire et les troubles de l'alimentation, ainsi que le traitement des maladies immunitaires, cardio-vasculaires ou des maladies liées au coeur, et de l'hypersensibilité du côlon associée à des perturbations psychopathologiques et au stress chez les mammifères.

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