Process for synthesizing remifentanil

Details Process for synthesizing remifentanil Process for synthesizing remifentanil

C - Chemistry, Metallurgy

07

D

C07D 211/66 (2006.01)

Patent

CA 2637951

A process for synthesizing remifentanil or carfentanil, as well as intermediates for use in the preparation of synthetic opiate or opioid compounds. The process comprising reacting a 4-amino 4-carbamyl piperidine with a base in a closed reaction chamber at elevated temperature and pressure to form to intermediate which may be esterified with an alcohol, alkylated, and acylated to produce a synthetic opiate or opioid compound.

Cette invention concerne un procédé de synthèse de rémifentanil ou de carfentanil, ainsi que d'intermédiaires intervenant dans la préparation de composés opiacés ou opioïdes synthétiques. Ce procédé consiste à faire réagir une 4-amino 4-carbamyle pipéridine avec une base dans une chambre de réaction fermée à une température et une pression élevées pour former un intermédiaire qui peut être estérifié avec un alcool, alkylé et acylé pour produire un composé opiacé ou opioïde synthétique.

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